NL25 QQ Question

[WantToLearn]

Ok, here comes a pretty general question, I know this is highly dependant on opposition and situation, but, as far as a general answer can go:

When I have QQ and there is a non-steal raise from an average opponent, and then there is a 3-bet from a player who´s tight enough that a 3-bet actualy means something, can I fold my QQ or am I hurting myself?

What if I 3-bet and a reasonable player behind me 4-bets?

Assume 100BB stacks please.

I have never befor considered folding but recently, and I simply can´t tell is this paranoia or awareness.