FL 1-2 Nut low, no high draw

[fatass748]

I know that this is a really situational question but any insight is appreciated. I'm really just learning this game still and was wondering when it is right to hold on to nut low with little to no chance at high. For example.

Holding Ah 2h 3h 4d on flop of 8s 6c 3d

It's almost impossible to get counterfeited. How many people need to be in this hand in order for it to be profitable?