Can you/SHOULD YOU fold it?

[3N1GM4]

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If he's noticeably tight and pushing in that particular position,

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Doesn't the fact that he's under immediate pressure from the blinds open up his range somewhat? I would be more inclined to fold if I was on the button and he was the CO, where I know he is happy to give up a whole orbit of possible hands to play what he has now... As it stands, he's going to lose almost half his stack to the blinds in the next 2 hands... Does this factor?