Stacking off with 2nd or 3rd nuts to massive overbet

[John49]

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I know the mods frown on "general" posts, but this has been bugging me a lot.

Scenario:

You have the 2nd or 3rd nuts, or the nut flush on a paired board, you have little money invested (let's say 3-5BB for sake of discussion) and your opponent open pushes or check-raises AI for 80-100BB.

Is it profitable to call?'

It could be just from running bad, but I rarely rarely ever see a worse hand here.

I'd like to see what you all think and hopefully have some meaningful discussion.

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Of course this matters. To me, it's an easier call earlier the street.