Are most scientific studies screwed up?

[Rduke55]

Agreed about Science and Nature. Some of the papers in there are amazingly crappy.
Funding is pretty screwed up. I think the publishing and funding have the same problem. You have these dinosaurs taking the lion's share (is that mixing metaphors?) of publishing and funding and acting as gatekeepers.
A recent bar conversation we've been having is how to fix it.
How would you suggest fixing it? I'm pretty evenly split between public and private funding and they are both screwed up (maybe for different reasons).