basic 2-4 hand, raised on river

[MHP]

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Villain 3bet preflop. Not on the flop.
Villain didn't checkraise the river, he just raised it.
Calling a 'chunk of your stack' doesn't matter. This is cash, not tournament.

Not sure if that changes your opinion or not, but they are important differences.

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I knew the 3 bet was preflop- that was a typo on my part. I thought this was a checkraise, but it was only a raise- this does change things- makes me lean toward calling. Seems more likely he detected weakness and thinks he can steal. Probably still a 60/40 decision slightly leaning towards folding. Its still largely a decision that is villian dependent. I would probably call an aggressive player here to send a message that he can't reraise me without a hand. If villian recently lost a big pot I also lean towards calling. If the guy only puts his money in with the nuts you fold.