Help with adaware/ DLLCACHE

[RR]

My wife has been using this computer and randomly downloads crap. I know I know I have spyware I need to get rid of, but when I run adaware it locks up when it is searching c:\windows\system32\dllcache. At this point it has found 28 items. Is there a way to manually do through and remove these items as it comes to them? I have sun spybot search and destroy and removed all the items it found.