a pair of 40/80 bb hands

[tessarji]

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If I know her raising standards include hands like Q9s, should I still fold?

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Yes.

You are out of position and this hand is likely at the bottom of her range, and she probably folds it and similar hands much of the time.

If she establishes herself as a maniac by continuing to raise this and worse hands, you can start fighting back by re-raising her (preferably with position) and going to lots of showdowns.

Saying 'I saw this guy once raise with 75s and he got a lucky flop so now I never fold anything HU with him' is not only moronic, it is a major reason why good players raise with random hands on rare occasions.