LO8 Preflop spot, what are standards for calling/3betting here?

[2handed]

This spot came up quite a few times in the 50/100 6max game I was playing last night.

Player A (unknown, first time playing with him, 'bioxu' i think, wasnt very good) would open raise in the first two spots around 40-50 percent of the time.

The guy to his right would proceed to call about 40 percent of the time and 3 bet around ten percent ('sopwith', if i remember correctly, who plays alright but I feel like I have an edge on postflop, somewhat loose player, regular).

The two players to my left in the second half of the session were both excellent O8 players, "Hakallah" or Wintermute, and Jennifer Harman (learn chat and play with the pros).

In the first half I had much weaker opponents in those seats but I don't remember all their names, 'mud_pie' was there for a bit, 'hotstuff' as well.

I was then often left on the button or in the CO with a decision whether to 3 bet hands to try to isolate the pot 3way (the two to my left were not folding preflop once they voluntarily put money in the pot) or to call and bring the blinds in. Obviously the decision to try to isolate became easier with Hak and Harman to my left, but I would like to know how people adapt their preflop based on the ranges they put the first two players on and the strength of the players to the left. GIve specific hand examples. If you call with a high only hand, how strong does it need to be?