Hero opens from Button - 3bet by mcTAG in the blinds.

[Khumalo]

My limited experience indicates that a mixture of the methods mentioned in this thread works well, and you can change things up based on situational factors.

For example, if I am up against a regular or someone I have history with or some guy I expect to be playing against for a few hundered hands, and he's 3-betting light, I might use the CTS-inspired 4-bet shove with Ax/AA/KK, adjusting my Ax frequencies depending on flow, how villain is attempting to adjust, what got shown down, etc.

Under more volatile circumstances, I will switch between light 4-betting 2.25x (folding bluffs to a shove) and calling somewhat light in order to shove/call-down on certain flops with certain ranges.

In general, I am more likely to see flops with hands that can make two viable pairs (+ draw) like KJs, and bluff 4-bet small with something like A3s, but I vary things.