Optimum bluffing strategy situations in NLHE

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In Theory Of Poker, Sklansky presents the optimum bluffing frequency, which simply implies that the pot odds you give your opponent are the same as the odds against your bluffing.

This makes perfect sense, especially in draw poker, where all of your cards are hidden, because then you can just say, for example, if you´re drawing one card with a flush draw: "I´ll bet with all the cards that make my hand, plus an additional 3 cards, as a bluff." But what about holdem?

I would like some clear cut, "standard" NLHE examples where you, against an unknown or good player, bluff with an optimum frequency so you don´t risk taking the worst of it with your bet.