Is this foldable for one bet?

[KenProspero]

Very loose 4-8 game at Canterbury.

I’m dealt QJ(diamonds) small blind – 5 or 6 limpers – I complete.

Flop is QJX (2 spades). I bet, 2 callers.

Turn is T (spades) I bet, same 2 callers.

River is A (spades) – I feel I’m sunk – so many ways to lose -- (Higher two pair, 4 spades on the board, 2 callers, plus there’s a 4 to the straight on the board.)

I check, Caller 1 (UTG) checks, Caller 2 (UTG+2)Bets

Question 1 – Do I call or Fold here.

Caller 2 has been sneaky in the past and I feel he’s fully capable of bluffing here, so I call the one bet. (probably a mistake)

Caller 1 raises, Caller 2 folds.

Question 2 --- Do I call or fold here?

I took a lot of time here. Caller 1 is a college kid, has only played a few hands so I have no read on him at all, though he looks comfortable at the table.