Calling Minimal All-In River Bets

[HobbyHorse]

Here's the situation (and it's a hypothetical generalization based on many separate experiences):

Say the game is NL and you're to the river with one other player. The pot is $250. The other player (first to act) shoves all-in with his last $50. Now, what exactly should your considerations be in this situation because isn't the math itself pretty irrelevant - you're obviously getting great odds to call but if you don't have two pair or better should you even bother? I guess what I'm asking is if you should let your knowledge of the player themselves and/or your own cards completely overrule any odds you're getting in a situation like this...
[img]/images/graemlins/confused.gif[/img]

What's your take?