Generic Advice for 1 - 5 spread limit?

[habsfanca11]

I've got a co-worker that I'm mentoring in poker who will be going to Vegas next week and playing in O'Sheas 1-5 spread limit game. I would like to pass on some advice but am really unfamiliar with this game. Does it play like 3/6? Do you bother varying your opening bet? Say like Aces, Kings and Queens are $5 but A,K is $3? Looking for any thoughts or considerations. As mentioned I have no clue about this particular game.