San Francisco Bay Area: Your favorite things to do or places to go

[The DaveR]

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quick question: I am thinking of taking my wife to sf for her birthday weekend in july. many of the hotels on expedia are 2-3 blocks from union square, is this an ok area to stay? I'm mainly interested in easy public transportation access, and not a super ghetto area.

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East of Union Square is good, as is south. As you move north (assuming it's not Nob Hill, which will often be separately designated as its own neighborhood) you'll start hitting Chinatown. 2-3 blocks west isn't a particularly good neighborhood. Lots of homeless but if that doesn't bother you it's perfectly safe.