When is the pot too big to fold.

[antneye]

An answer I gave in another thread leads me to ask this question.

How many bets need to be in the pot for your 1 bet call to become automatic on the river?

There has to come a point where your read cannot be accurate enough to offset the pot odds you are being offered. Is there any magic number you use to cross the threshold and disregard what your heart and brain are telling you the villain has?