[Xylocain]

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How do you play against those guys? There is usually at least 4 to the flop, 3 to the river.

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The problem is that this cannot be solved by any quick fix ... because;

either you move up where people respect your raises so that you will have only 1 opponent at the river (win ~50%) but the variance is higher so what you gain by having fewer river opponents you will loose because of variance.

or you move down but there people dont respect your raises at all so you will have as many as 5 people to the river which makes it even less likely that you have the best hand.

To make things worse, 0.25/0.5 is probably the level where the cumulative effect of those two effects highest. This is best compensated by moving between levels which allows you to play your weak hands against few opponents at high levels but strong hands against many opponents at low levels. Of course knowing when to play a hand at high or low comes only with thousands of hands of experience and that is what makes a winning expert LHE player.

hth
-X