My favourite show is
Red vs Blue. I'm not sure if it qualifies as "little known", but I wanted to mention it anyway.
From wikipedia:
[ QUOTE ]
The series chronicles the story of two opposing teams of soldiers fighting a civil war in the middle of a desolate box canyon (Blood Gulch), in a parody of first-person shooter (FPS) games, military life, and science fiction films.
[/ QUOTE ]
This is just plain hilarious stuff. If you've ever played any fps semi-seriously, you'll have a blast watching this.