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selection operates not by the survival of the most fit

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I agree in general (though I'm not a transhumanist), but I'm going to pick this nit. Selection always works by survival of the most fit, based on the definitions of "survival" and "fitness." This is true even of "technological evolution" and genetic engineering.

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I agree with you.

I just wanted to point out the difference, as the survival in a 'natural evolution' will be different from survival in 'technological evolution'. As an example, we can select for a certain quality, such as red eyes, and we will be able to engineer red eyed mice much faster than it could occur in 'natural evolution' (if the 'red eyes' gave some advantage to the mice). In other words, the influence of chance in the 'technological selection' is smaller than in a 'natural selection'.