[Fadook]

OP, you playing at OnGame? Sounds quite similar. I've just had a really bad run there and have been thinking about the adjustments necessary. Here's some random thoughts:

Steal less. If you have a hand that relies heavily on people folding to win, don't raise. Consider folding or even limping.

In a similar vein, don't bluff. C-bet the turn far less when you have nothing. If they're not going to fold, so what?

A lot of these guys tend to be quite passive. So when they raise, strongly consier hitting fold. It can be hard to believe that they could actually have a hand that beats you when you see how uncoordinated the board is, but as you've said, they're playing close to any 2, so anything's possible.

To make up for the fact that you're playing a lot more weak-tight in some spots than you would against a more rational line-up, value bet a lot more. TPWK, middle pair, these are hands you need to bet on every street, including the river.