Clone High is excellent.
My pick:
Wonderfalls
It's about a girl who is overeducated but lazy and useless and works in a crappy gift shop at Niagara. One day inanimate objects start talking to her, and wackiness ensues. It's great, and very funny. Like the more well-known Firefly, it was stuck on Friday night and cancelled quickly by Fox, but - also like Firefly - there's a nice DVD set of 14 episodes.