[seki]

People often don't take into account the fact that playing a hand a certain way affects the profitability of other hands by perhaps a greater margin than the hand itself.

Yes, to cite the most common example, maybe with your image, raising 22 in EP is -EV for you, but if you continuously do it, your big EP hands get more action. And if it works with your style, the +EV of the other hands compensates for the -EV of the 22, etc.

Regardless, blanket statements of you "should" do this or that are always wrong. The profitability of playing one way or the other is wholly dependent on your image, the table, and *how you play the rest of your range*. Arguing about one variable in a multi-variable situation isn't the most worthwhile exercise. Just keep this in mind: There is no 100% perfect NLH strategy, unless everyone at the table is using it (in which case you're stupid for playing poker at a raked table). So, please be more restrained in saying concrete statements like 'doing X is always bad/good'.

Unfortunately, this is one of those irritating poker questions that will show up continuously, and have the same cookie-cutter responses.