[Corpsebean]

I'm right handed and the first game I ever got that was mouse and keyboard was Quake I. I went to play multiplayer and since arrows looked like the default I just used the mouse in my left hand.It's been 10+ years now and I use left mouse for everything despite being right handed, and am actually really gimped if I try to use my mouse in the right hand.

Personally I use Arrows for movement, but always have 2 side buttons on mouse to utilize a couple other functions (Lean left and right in COD4).

I generally always use Ctrl for crouch and Keypad 0 for jump, shift for reload and still have access to most of the left oriented keys and the 6 home/insert/etc buttons.

Works pretty well for me, my one complaint about using arrows is that given the space and lefthandedness of mouse really leaves me with a lame selection of mice.

IE I have to use a logitech G3, which is okay but I'd love to use the right-hand countoured G9 or whatever.