10 days?? When I was in college I'd need a liver transplant after about 5. I assume you guys will be drinking a storm so I'd break up the week a little by doing some outside stuff. Rent a couple cars and go to Valley of Fire or closer by you can go hiking at Red Rock Canyon. Can also go to the grand canyon if you have that amount of time. It will be nice enough at Mount Charleston I think to hike - ?is there still snow up there then?
There is an indoor gokart track that I have not been to but a good friend of mine says it is a blast.
I would spend a few nights downtown. They have opened up some reasonably cool bars down there to go to.
Look up the list of Dive Bars in the Las Vegas Weekly paper web site and go on a Dive Bar crawl.
http://www.lasvegasweekly.com/2004/01/01/cover.html
Don't miss Dino's on a thursday-sat for dive bar karaoke.
http://www.dinoslv.com/
See a show at House of Blues. Great venue - the joint is also cool but not as many shows there. Purple Reign play at HOB and the brew pub and is a great show
http://www.purplereign.net/10.html?sm=29619
If you really want to be adventurous go to the Green Door - I'll let you google that one yourself.
Reserve a table at ESPNZone and watch the bball games and run up a huge bill.
Before I moved here I went on many trips with a big group of guys that drink a ton - we would always be in various states of hangover and sleep deprivation so it is hard to get people motivated to do stuff without a plan - and if I was here that long I would definitely want to have a big list of specific stuff to do so you don't just wind up drinking at a sports book for 12 hours every day- which is fun but not for 10 days!
edit: I was just reading my dive bar link again and a couple of those places have closed
RIP Rice Paddy and Bond-Aire club. I will miss ye!