Mass Effect looks pretty sweet, supposed to be a 3rd person action RPG in space. I just wish they didn't cast the pimp/drug dealer from Requiem for a Dream, I can't hear his voice without thinking about the ass to ass scene.
http://www.gametrailers.com/player/11790.html
http://www.gametrailers.com/player/21498.html
http://www.gametrailers.com/player/21471.html