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Absent specific reads IMHO, it comes down to position. When you're OOP, you almost have to raise. With the button, whether you raise or not really depends on the actions of the players in front, and your strength against their range. If they've all limped in, raising to get people out isn't viable: they're priced in. In that spot, a raise would be to build a pot when you have a monster, or induce them to give you a free draw on the next round (less likely against calling/betting stations, of course).

Granted, I haven't been playing 2-7 as long as most of the people here, so my comments might expose some holes in my game to someone more savvy. But I play a lot of limit poker, and I get the impression the limpers are NLHE players coming in and giving the game a try that are not comfortable with Limit games.