[drzen]

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Most people around my area just say "81" (for Interstate 81) or "70" (for I-70) for the two interstates. "Take 81 South to 70 East to ..."

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This is very standard.

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This would be comically illiterate here and in the UK.

"Take the M1 south" every time.

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Would you say turn onto the Main St. or take the 3rd Ave north?

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No, never.

I don't know why not.