[astroglide]

[ QUOTE ]
The straight up best is WASD. Nothing else gives you access to the same range of additional buttons.

[/ QUOTE ]

i think ZXC is better than WASD for sub-second weapon switches. with WASD, getting to Z/X aiming, and firing while maintaining fluid motion is much more difficult for me than going up and homing back for keys using ZXC as the root position. i'm talking about absolute twitch timing, like railgun-fire-rocketlauncher. i use my right mouse button for movement as well, so S isn't even my forward. here's my essential quake 3 layout:

Z = strafe left
X = run back
C = strafe right
A = plasma
S = rocket launcher
D = railgun
E = shotgun
W = lightning gun
Q = machine gun
R = grenades
SPACE = jump
MOUSELEFT = fire
MOUSERIGHT = run forward