[Sounded Simple]

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do some ev analysis with specific hands (i.e. 88, KQ, 89s) vs specific late position raising ranges (i.e. top 10%, 20%, 30%) to figure out what you should be reraising/calling/folding.

This is one of the toughest situations in poker and its what often separates a big winner from a small one.

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Is pre-flop equity important if we are 100bb deep and its 4bb to us?
If your shortstacked or in a tourney then its all important - since your usually shoving

Deepstacked I cant help worrying about reverse implied odds - i.e. making a second best top pair hand with KQ, raised pot, OOP.
Maybe a small pocket would be better for 3-betting from the blinds since you can either flop a monster or miss and take a stab then shutdown?

Maybe Im overthinking again - Im a 50NL player so perhaps I dont have to worry about this yet.