[XXsooted]

PM, the hand seems to be more read-dependant than anything since you're claiming this guy folds an overpair way more than anybody I've ever seen, especially considering that you've been active in recent hands.
One thing to consider is that if the players on your table are really playing this weak and you have strong reads on them you probably want to err on the side of caution when it comes to marginal decisions for a large percentage of your stack.