[JackCase]

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Ed Miller explains this really well in his DVD set.

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Don't keep us in suspence - What did he say?

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You "pay the blinds" more often in 6-max, but the blinds have more equity because they are facing fewer potentially good hands. This is because there are simply fewer players ahead of the blinds, and because many of the opponents are playing weaker hands than they would in a full ring game. They play looser because they incorrectly believe that you have to play more hands, and play them more aggressively, since you pay the blinds more often.

So according to Miller, you don't necessarily loosen up early in 6-max, but you should defend your blinds more vigorously, especially the big blind, because you have more equity and because you will be getting called or raised with weaker hands, especially from the button, than in a full ring game.