[kyleb]

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Hasn't prolonged exposure to low levels of adrenaline been associated with and said to be causative of some extremely unhealthy things?

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I've read a bunch of journal papers on this very subject, and the only things I can take from them are:

Prolonged exposure to adrenaline can result in:
-Increased sensitivity to insulin as it relates to glycogen stores
-Tolerance to adrenaline compounds (obviously)

However, I found nothing that confirms the idea that increased and prolonged exposure to adrenaline and precursors to adrenaline could cause anything negative as related to the endocrin system.

There is significant anecdotal evidence on various personal logs that show that by taking ketotifin or the active ingredient in Benadryl (diphenhydramine) can uptake the receptor sites for these types of cAMP stimulants to retain their effectiveness, and that over months of use, no negative effects have been reported.