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Poker Tracker is basically a database, and I understand Poker Office is the same thing. I love PT, and you can use it with Poker Ace HUD to get real-time overlays on the table.
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PokerOffice is a database and real-time overlay program all in one. It will also give you odds and outs on the possible hands you can draw to. They have some deals also where you can get a copy for free if you open an account at one of its affiliates, including most major sites such as Poker Stars, etc. I also like the way it will give profit graphs (and other customizable graphs) and show you how you are doing (as well as opps) on various types of flops, such as open flush draw, etc. How much of a profit or loss is incurred depending on the types of actions you take. Excellent for helping plug leaks. And finally, not to be overlooked: a far nicer interface.
Albert