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To be clear, I'm mostly looking for fun stuff to do in Philly, as I want to explore the city while I'm up there. I can't imagine there's too much to do in Reading.
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1) Eat a cheesesteak. My personal favorite is Jim's with Pat's a close 2nd. Jim's has a location on South Street, which is another part of town with lots of bars, music, nightlife, etc. Pat's is located right across from Geno's (those two are probably the most famous Philly cheesesteak places).
2) Manayunk ... like I said, tons of bars, clubs, etc. You can pretty much just wander around town, if you want some particular places, Grape Street Pub often has good local bands, Bourbon Blue is also pretty decent. Manayunk Brewing Company is a good restaurant with lots of homebrew beer. This looks like a good website for doing Manayunk research:
http://www.manayunk-pa.com/mpa/bars.asp
3) If the Philly Wings pro lacrosse team is in town on the weekend you're around, that's a surprisingly fun time.
http://www.wingslax.com/
4) There's a ton of culture/history if you actually want to check that out...obv Liberty Bell, Indepence Hall, etc. Franklin Institute is allright and they have the travelling King Tut exhibit right now which is supposedly cool, I'll be checking that out later this month actually. We have a good art museum too.
5) If you want to go out for a really good meal somewhere, pick one of these Stephen Starr restaurants (you'd probably want to call ahead for reservations) ... he owns a ton of great (but pricey) restaurants around town.
http://starr-restaurant.com/