[creedofhubris]

Take one extreme case, the jam/fold game. Let's say the big blind has announced that if you go allin, he will call without looking at his cards. Obviously, he is being way too loose. The "optimal" raising system goes out the window, and you rely solely on EV calculations, looking at which hands are +EV vs. any two cards, given the blinds.

Where ordinarily you might raise with suited connectors, now you must throw them away; and whereas, if blinds were deep enough, you might muck A2, now you raise with it. So it's a mix of both; some hands go out the window and some hands are added.