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With less players left to act one doesn't need as good a hand as the chances have gone down that one will face a stronger hand too often. There's a mathematical formula for that, and there are software runs (showdown runs as well as simulated) and there are real stats (pokerroom.com may still have them, not sure) per limit and the number of players still to act (played by all players, good and bad but most these days may play at least decently).

With 6 players left in a full ring game one needs to be marginally tighter than when it's a 6-max game as when no-one is yet in the pot in a 10-max game there's a bit better chance that the remaining players will have a better hand, though it's marginal, and then people in 10-max games (even when it's shorthanded) rate to be somewhat tighter preflop and/or after the flop, so it effect the hand values too and how one should play them preflop and after.

What one should play out of position like three of the button (6-max under the gun) depends of game conditions too, e.g. it's not too good to go open-raising XT, X9s, (22 is good if the big blind won't call with lesser hands but if that's not the case one would like 77 that should be good under any but too loose conditions) when one gets 3-bet with any semi-playable hand and the big blind doesn't fold often and the after the flop play is tricky and tough. In that case one needs to be tighter and either fold or limp with the weaker hands to get a better mix between the showdown/4-bet starting hands and the weaker starting hands, though one generally gets raised more often when one limps (and one is obvious, but it still doesn't mean one can't make money, e.g. one has the position over the blinds who have weak hands) than when one open-raises, meaning one would be better to open-raise, especially as one normally does steal the big blind at least some of the time, in case the simulations clearly indicate open-raising being a more profitable play than limping, but they can't be trusted 100%; one needs to think and feel it by experience too.