[guids]

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But science, and scientifically inclinded folk are far more comfortable with an end result of "dunno" than most.

Obviously a drive for exploration is great. It's when that bricks out that I see mistakes being made. Obviously religion is the best example. (warning, crude, inartful example follows) We cannot rationalize how we got here, etc, so some folks made up a Unicorn in the sky to help them get through the day.

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Science cannot rationalize how we got here. There are plenty of people who believe in god that have no trouble rationalizing thier existence. You say they believe in a big Unicorn, but most of them, while in your opinion may be ignorant, are probably much more happy and at peace with things (ecspecially near the end of thier days). If ignorance is bliss, i have no trouble being happy.