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ok i have played this game for two days straight and have 5 starred about half the songs on medium
brag: i play lefty with the standard GH2 guitar kurt cobain yo
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Cobain played standard left handed guitars as well as RH guitars. You might also be thinking of Jimi Hendrix or Albert King. Hendrix turned a RH guitar around, but also changed the strings such that low E was the top string. King turned a RH guitar around, but played it such that low E was the bottom string.
http://en.wikipedia.org/wiki/Albert_King