What is the most tragic thing you've ever had to deal with

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I've had some similar stuff. I'm 39 and the generation before me is older. Almost every has to or will have to deal with this stuff.

One of the worst situations I've ever even heard of is in my family though. One of my relatives had an infant daughter that was killed by the father who then tried to beat her to death, leaving her for dead with some brain damage. Not long after that she cancer and had to go through chemotherapy.

She's recovered physically, is generally very upbeat, and extremely supportive whenever anyone else needs help in the family.