Adware Problem

[NoahSD]

So I was dumb and downloaded some sketchy software and now have all this crap on my computer. When I first opened the software, my antivirus (trend micro PC-cillin) pops up and tells me that I have a bunch of trojan viruses, but it's gonna "quarantine" them. So I immediately delete the stuff I d/led.

Now, like every 3 or 4 minutes, one of a few different ads sites will pop up. So I tried using spybot and ad-aware, and both of them gave me that message that I had some stuff that was running, so they needed to clean it up at next boot. However, neither of them opened when I restarted. I repeated the process and nothing.

What do I do?