[ama0330]

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I've always played FR, just switched to 6 max- played 12k hands won about 12BB/100, so I'm off to 25NL- what's the single biggest difference and where should I focus my efforts now?

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Aggression and table dynamics. 6max is far more aggressive than FR, and you play a lot more hands. You should focus on learning how to be aggressive and how to respond to aggression.