[QuickLearner]

Good question... There's a lot more to think about than whether you hit the flop. I'm going to asssume that you mean A10s as well as A9s and not A10o (which is a big dog from early position and isn't much of a prize even on the button!). And I'm also going to assume you're playing no-limit.

Here are a few questions to start the discussion:

Are you playing a full stack? Are your opponents?

How do the players at the table perceive you? And what is your opinion of them? Are you plsying in an aggressive game, or is everyone pretty passive? I know you said you know nothing about them, and if that's the case how does that fact influence your decision to play?

Are you willing to fold your hand if you face significant pressure and the flop doesn't hit you hard? And by hard I mean at least top 2 pair?

How many opponents do you want to face with these hands? What action will you take to get what you want?

If you play and flop an interesting hand (like a flush draw, straight draw or one pair) how much will you have to pay to get to the showdown? Here's a spot where it would be helpful to know your opponents...

That's enough to get us started.