[ElDuque]

I've enjoyed this thread, however, I think that a lot of posters are missing the exact point of the topic. What we are discussing is -- as the title says explicitly -- the consequences of long-term use of hard drugs.

I would argue that it is highly unlikely -- like 10^-6 unlikely -- that any person with a reasonable expectation to a decent quality of life would have their quality of life improved by the REGULAR/HABITUAL long-term use of any illicit drug (inlcuding LSD, Shrooms), except pot. Although, I think it is still unlikely that this type of pot use would be beneficial to life quality.

On the other hand, I would argue that short-term or very infrequent use of some illicit drugs (LSD, shrooms, Pot, MDMA and some others of this nature) COULD indeed enhance the overall quality of a peron's life.

BTW, I have no evidence to support this. It is pure speculation.