[mvdgaag]

Game theory uses randomness to choose an action. This works for bluffs when your opponent doesn't see a part of your hand.
If he gets to see the river card that you choose to bluff on (like your example in the theory of poker, but now it's holdem) he knows it is more likely you are bluffing if it's a blank than if it might have made your drawing hand. So game theory is flawed here.
The same applies to strategies. Your strategy reveales itself a bit by your actions on previous streets like that rivercard revealed your bluff. I think that if you'd randomise your strategy every hand, it's very, very hard to determine that strategy for your opponents. It will probably work great for most players, but real good players might have better results by choosing their strategy by judgement of the situation/game.