[arahant]

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With that level of vagueness, no. I'd concede that if the fight STARTED on the ground, that the skilled MMA fighter would almost certainly be a heavy favorite.

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I'm by no means world class in anything. That said, I have no doubt that I could take down almost any boxer, of any size, very quickly. Admittedly, one ungloved, perfectly-distanced punch from a pro boxer would lay me out immediately, but it's hard to deliver a solid punch at a guy who is going for your ankles or stepping to your shoulder.

I think you vastly underestimate the ability of grapplers (and most martial artists, for that matter) to close distance, minimize damage from a single blow, and take someone down. It's just not even close.