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OP: Is the number pattern independent of the letter pattern?

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the XXX is derived from the 3 sets of given numbers. the ### is derived from the XXX AND the given numbers. and its quite tricky, even with this hint.

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Since the XXX is derived from the 3 sets of given numbers and the ### is derived from these as well as the XXX, doesn't it follow that the ### is derived soley from the 3 sets of given numbers?