[Kyo Souma II]

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LSD should be number one on everyone's list. No chance of overdose and no bad side effect while offering a mind bending experience stronger than any other psychadelic.

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LSD is probably the third most likely drug, after E and benzos, to exacerbate a pre-existing or as-yet undiscovered mental condition.

Oop. Left PCP off that list. Oh well.